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Consequently, with BPC 157 therapy, the clear counteraction, which occurred in the rats which have the permanent occlusion of the superior sagittal sinus, as before in the BuddChiari syndrome-rats or Pringle maneuver ischemia, reperfusion-rats [26,27] and other venous occlusion studies [20,21,22,23,24,25,26,27], may suggest possible BPC 157 therapy effect in patients as well

Periodic transaminases measurements should be made during prolonged treatment with diclofenac because severe hepatotoxicity may develop without a prodrome of distinguishing symptoms

These features need to be taken into consideration when trying to develop new in vitro models