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have demonstrated that the hydrophobic loop of -SNAP is important not only for the coordinate binding of -SNAP to membranes but also for promoting or driving membrane fusion 12

The proton taken up by Glu272 is subsequently transferred to a hydrogen-bonded water chain as Glu272 rotates 170 to hydrogen bond a water molecule, in turn hydrogen-bonded to a propionate of the b L heme

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Diabetic retinopathy manifests in different forms: non-proliferative DR (NPDR), characterized by microaneurysms and retinal hemorrhages