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doi: 10.1136/mp.54.5.311 H
In turn, Per and Cry dimerize, acting as the negative limb of the feedback loop to inhibit Clock:Bmal1 transcriptional activity for the cycle to repeat, and degradation of Per and Cry proteins are responsible for terminating repression and restarting transcription
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Research also suggests it plays a regulatory role in the hypothalamicpituitaryadrenal (HPA) axis, helping to support balanced cortisol rhythms and a more adaptive stress response
