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GR protein turnover is greatly stimulated in response to glucocorticoid binding through ubiquitination and subsequent proteasomal degradation ( 2.3 Glucocorticoid receptor physiology: molecular mechanisms of action 2.3.1 Genomic mechanisms of action GR is localized in the nucleus, cytosol, mitochondria, and cell membrane ( Figure 2 )

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For immunoprecipitation samples, the database search was performed using the CHiMA 2.0 strategy 39
