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Consistent with the upregulation of ZnT8 observed in human diabetic cells, ZnT8 expression was significantly increased in cells from HFD-fed mice compared with those from ND-fed controls (Supplementary information, Fig

SIRT1 further inhibits sterol regulatory element-binding protein 1c (SREBP-1c) to reduce fatty acid synthesis and activates peroxisome proliferator-activated receptor (PPAR) to promote fatty acid oxidation

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However, no difference was found between the two groups when comparing changes in total glutathione levels (responders p = 0.05, non-responders p = 0.06) (Table 4)