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It is important to note that this increased cell reproduction can lead to the worsening of the disease or relapse in people with a family history of the disease

Indeed, promising data have been reported using the novel agent NT157, which inhibits both IGF-1R-IRS1/2 and STAT3 signaling in tumor and stromal cells, and has potent anti-tumor effects in preclinical models of melanoma and colorectal cancer [158, 159]

A deficiency in glutathione can lead to increased oxidative stress, reduced detoxification capacity, and compromised liver function

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