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GCLC and GCLM together form the rate-limiting enzyme in glutathione synthesis, glutamate cysteine ligase
Overall, therapeutic interventions targeting amino acid metabolism may provide novel biomarkers and treatment strategies for autoimmune-related diseases, but their clinical translation still depends on higher-resolution human validation and mechanism-oriented precision studies
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Succinate Dehydrogenase (SDH) and Fumarase: These enzymes also modulate the TCA cycle through their activity in the interconversion of metabolic intermediates, impacting the flow of -KG
