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Pediatric Use: Pediatric patients' safety and efficacy have not been shown

In primary cardiac cells, Cu2+ has been shown to increase interleukin-6 release and activate MAP kinase (69), contributing to cardiac inflammation and hypertrophy (59)

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[71] "An in vivo study in mice fed an obesogenic diet (high fat and high sugar) with or without vitamin C found that vitamin C reduced body weight gain, particularly in terms of fat mass, compared to mice fed the obesogenic diet alone." Click To Tweet A clinical study in 22 men and women between the ages of 18 and 38 years evaluated the relationship between vitamin C status and fat oxidation during exercise