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However, in the largest RCT to date, there was statistically significant improvement in curvature and plaque size in patients receiving topical applications of verapamil (15% twice daily) over the course of 3 months

Habib, T
10.1016/j.yexcr.2010.05.019 120 WuR

Patients were randomized in a 1:1 ratio to receive ALC (500 mg) or MC (0.5 mg) three times daily for 24 weeks
