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RegeneRx Biopharmaceuticals developed TB-500 through early clinical stages, including Phase II trials for wound healing and dry eye syndrome

Additionally, TB-500 in commercial products refers specifically to the N-acetylated 1723 fragment (Ac-LKKTETQ), while the strongest peer-reviewed clinical and preclinical work was conducted on full-length thymosin beta-4 (RGN-259, RGN-352)

Still, their stability drops significantly after reconstitution most reconstituted peptides are considered reliable for no longer than 28 days under refrigeration, which is precisely why the shelf life of bacteriostatic water aligns so well with typical peptide usage cycles

In these studies, AOD 9604 was generally safe and well tolerated