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An oral gavage delivering a substance directly to the mouses stomach

The term represents cessation of optimal secretion of somatotropin (hGH) which is analogous to declining production of reproductive hormones during the menopause and andropause in women and men, respectively

Acknowledgments This work was supported by the National Institutes of Health R01DK121797 (T.D.H), R01DK126884 (D.E.S.), and the National Heart, Lung and Blood Institute P01 HL05197-11 (D.E.S.) and K01HL125445 (T.D.H.), and the National Institute of General Medical Sciences P20GM104357-02 (D.E.S.)

Of interest, SASP released by tumor cells after TIS induces transmission of senescence to non-senescent neighboring cells (162, 163)