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The TLR4-NF-B pathway is also inhibited by SSB2 in LPS-induced microglia, which suppresses the activation of microglia and reduces the levels of IL-1, IL-6, and TNF-, increasing the anti-inflammatory cytokine IL-10 (Wang et al., 2023)
Artificial formation by autoxidation can be minimized by adding butylated hydroxytoluene (BHT) or another antioxidant
Townsend, 2007)
While the depletion of cysteine and the accumulation of cystine and Met-SO clearly indicate increased oxidative stress in SLE, none of these compounds or the unique PPP substrates R5P or S7P correlated with disease activity of untreated patients
