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This intertwined complexity in both machinery and assembly is not conducive to traditional genetic approaches to either label components or utilize knockout technologies to identify regulatory pathways

Proc R Soc Lond B 286:20191917 Plcido A, do Pais do Amaral C, Teixeira C, Nogueira A, Brango-Vanegas J, Alves Barbosa E, Moreira D, Silva-Carvalho A, da Silva MDG, do Nascimento Dias J, Albuquerque P, Saldanha-Arajo F, Lima F, Batagin-Neto A, Kuckelhaus S, Bessa LJ, Freitas J, Dotto Brand G, Santos N, Relvas J, Gomes P, Leite JR, Eaton P (2022) Neuroprotective effects on microglia and insights into the structure-activity relationship of an antioxidant peptide isolated from Pelophylax perezi

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Furthermore, the successful application of BoNT/A in experimental models offers valuable insights into its potential clinical translation in OA treatment