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10.1177/1947603519841675 207 PedrazzaL.Cubillos-RojasM.de MesquitaF

A., Li H., Tangney C

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Importantly, therapeutic strategies should target not only the source of initiation and/or progression of the disease but also self-amplifying mechanisms that sustain emphysema themselves, namely airspace enlargement, ECM breakdown, and progressive mechanical failure, all of which should hinder the self-perpetuation of tissue damage and stabilize lung architecture
