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The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, protein binding, active metabolites, and receptor interactions

Subsequent studies confirmed its predominant expression in the hypothalamus under physiological conditions

[DOI] [PubMed] [Google Scholar] 63.Shimizu S., Kitada M., Ishikawa H., Itokazu Y., Wakao S., Dezawa M

However, they still work by inhibiting COX enzymes locally
