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In the matrix, multiple enzymes work together to degrade misfolded, damaged, and oxidized proteins, as well as to turnover some metabolic enzymes, forming the CLPXP complex and Lon protease homolog (LONP)

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The proposed mechanism involves selective stimulation of fat breakdown (lipolysis) and suppression of fat formation (lipogenesis) via direct effects on adipose tissue, without the growth hormone-like systemic effects