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Description
In 2017, Jungs group reported the first-in-class triazole-based PROTAC
The SURMOUNT-4 trial found that participants who stopped tirzepatide after achieving significant weight loss regained approximately two-thirds of lost weight within 12 months
J Pediatr Pharmacol Ther 2020;25:149-54
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Meanwhile, propofol administration at varying concentrations (50, 100, and 200 mM) to isolated adult guinea pig hearts dose-dependently reduced oxygen utilization by myocardial cells, impeding the mitochondrial respiratory chain and diminishing the ventricular wall function of perfused hearts [28]
