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Avoid smoking & excessive alcohol: Both deplete GPX1 activity

Chemical modifications designed to improve peptide stability : incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization

When you are sleep-deprived, your body has less time to engage in the natural recycling process that turns oxidized glutathione back into the reduced form

This suggests that the dose-escalation schedule used for the 36 mg arm may have been somewhat better optimized to mitigate nausea than the schedule for the 12 mg arm, or that the higher dose groups achieved better gastrointestinal adaptation during the titration period