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Once reactivated, it becomes contagious again and can lead to a recurrence of symptoms, especially in people with compromised immune systems

doi: 10.3389/fimmu.2018.02134 Received 09 June 2018 Accepted 29 August 2018 Published 20 September 2018 Volume 9 - 2018 Edited by Fabio Malavasi, Universit degli Studi di Torino, Italy Reviewed by Benjamin Bonavida, University of California, Los Angeles, United States

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards