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Description
Using genetically engineered V79 Chinese hamster fibroblasts that expressed human CYP1A2, N(O)-acetyltransferase (hNAT2*4) and sulphotransferase (hSULT1A1*1), Platt et al
We hypothesize that irisin reduces lactate synthesis by inhibiting the HIF-1/LDHA pathway via SIRT1-mediated deacetylation and repairs mitochondrial function through the PGC-1/UCP2 pathway, ultimately improving neuronal damage
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