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Do not take ONIVYDE if you have had a severe allergic reaction to ONIVYDE or irinotecan HCl
Pharmacokinetic studies demonstrated approximately 38% oral bioavailability and blood-brain barrier penetration, unusual for a peptide-based compound and attributable to Dihexa's small size (504.66 Da) and hydrophobic modifications
Natl Cancer Inst 99 , 949961 (2007)
That said, the good news is that with the right care and treatment, it can be managed effectively
