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10.1038/nature05327
Studies on the mechanism of pentobarbital-induced GH release in the rat
This has been shown to reduce the sensitivity of AML cells to chemotherapeutic drugs such as 5-fluorouracil and highlights the importance of the tumour microenvironment on cell metabolism and the efficacy of drugs ( Another limiting issue is the lack of efficient culture media to accurately represent the tumour environment in patients ( in vitro and therefore these cultures better represent the cellular environment of patients
