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Origins as a Mitochondrial-Derived Peptide MOTS-C peptide was first characterized in 2015 by Lee and colleagues, who showed that stressed muscle cells release this peptide, which then translocates to the nucleus to upregulate genes involved in adaptive stress resistance

SCFAs can affect the blood-brain barrier, neurotransmitter levels, and neurotrophic factors, and directly stimulate the vagus nerve to transmit to the nerves, affecting gut-brain communication (Powley et al., 2019)

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This difference between NAD, NAC and NMN helps us understand their complementary benefits