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Therefore, it is highly demanding to optimize all components in order to obtain the best cereblon-based PROTACs

Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993

NAFLD is associated with metabolic syndromes and the incidence of NAFLD has increased over time [4, 5]

DNA Repair 2 , 7389 (2003)
