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Br Med J 316 : 894898

Relevance of Experimental Doses to Human Exposure A major challenge in interpreting the toxicological evidence on MNPs is the disconnect between the high, often acute, concentrations used in experimental models and the lower, chronic exposures experienced by humans in real-world settings

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498,499 Despite demonstrating superiority over placebo in treating moderate-to-severe plaque psoriasis, tofacitinib is not approved by the FDA for this indication due to concerns regarding its clinical efficacy and long-term safety