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According to FDA prescribing information, unopened pens should remain refrigerated until the expiration date printed on the label
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Standalone B12 injections contain only cyanocobalamin or methylcobalamin and are used primarily to correct deficiency or support methylation

Loss of CEBPB increases MHCII in tumors, recruiting CD4 + T cells that paradoxically promote metastasis via unresolved inflammation [98]