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Numerous studies have shown that long-term exposure to PM10, SO2, NO2, CO, cadmium and ammonia can induce and exacerbate inflammatory responses in the nasal cavity, leading to olfactory dysfunction (166,167)

The heterogeneity of clinical and behavioral features in children diagnosed with ASD contributes to the difficulty in understanding the pathophysiology of this disorder, and consequently, no specific treatment can be effective for all ASD children

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However, specific injuries such as traumatic brain injury, stroke, brain tumor, or aging are believed to compromise the efficiency of BBB protection, thereby allowing MSCs access to cross the BBB and deliver their protective effects