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513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism

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However, the CagriSema combination showed a higher odds ratio for diarrhea at 6.60 compared to semaglutide alone at 2.37

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