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Concurrently, damaged neurons have been shown to secrete CCL2(monocyte chemokine protein-1, MCP-1), a crucial chemokine that mediates neuron-macrophage communication [21]

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successfully developed nanocurcumin and arginine-incorporated chitosan hydrogel, which demonstrated the ability to enhance the phosphorylation of eNOS in endothelial cells in vitro , along with antioxidant activity, effectively preventing hypoxia-induced endothelial injury (Mohandas and Rangasamy, 2021)

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