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Furthermore, large-scale analysis of public -omics data has identified ALDH1A1 as a potential therapeutic target, providing a multitarget treatment strategy for future clinical research on NAFLD ( 4.4 ALDH1 and osteoarthritis Osteoarthritis (OA) is a highly prevalent and debilitating joint disorder for which no licensed therapies currently exist

Gene panels are currently an attractive option in clinical laboratories because of their reasonable costs, relatively acceptable turn-around time, decreased complexity of data analysis, better coverage over the regions of interest, and reduced incidental findings [96,97,98]

Cuprizone pellets are a more convenient route of cuprizone administration, as they can be commercially custom made and do not require daily replacement to ensure activity is not compromised by rodent urine

In the present study, we investigated the central effects of growth hormone (GH) on energy homeostasis as GH fulfills several requisites of an energy-deficiency signal to the brain