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however, higher ACSL4 expression corresponds to a lower IC50 value of sorafenib in RCC patients, indicating that these ferroptosis-related genes are closely related to drug sensitivity (Fig
1), also exhibits chemistry similar to cysteine, but its reactivity is distinct due to the different intrinsic chemistry of Se versus S and is enhanced at neutral pH due to its more highly stabilized deprotonated form (i.e., its lowered pK a of ~5.2) [1, 2]
When it comes to dietary sources, the delivery of gluathione is less precise and the quantity much smaller
Free Radic Res 21 : 267276
