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10.1186/1479-5876-11-24 95 ZhangM.ZhangY.XiaoD.ZhangJ.WangX.GuanF.et al (2020)

However, complete blockage of ECM attachment can be expected upon filling of type 2, 3 and 5 sites, as they contain Asp256 and Asp258, or Asp 300, which are directly involved in collagen binding 86

Often used as a layered approach

Additionally, Astaxanthin may help support the skins natural barrier function, enhancing its resilience against external aggressors
