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Fahn S., Oakes D., Shoulson I., et al., Levodopa and the Progression of Parkinson's Disease, New England Journal of Medicine 351, no

Although HC binds the bulk of plasma cobalamin (7590%), it is not involved in cellular cobalamin uptake apart from uptake in hepatocytes (Ref

Notably, the clinical phase III trial testing the therapeutic effect of Bardoxolone methyl, a potent Nrf2 activator, on chronic renal disease associated with type 2 diabetes was terminated because of an increased rate of cardiovascular events, including heart failure and deaths (Ouyang et al., 2014

References 1.Ludwig J, Viggiano TR, McGill DB, Oh BJ