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Description
During insulin therapy, iron uptake can be increased by increasing the transferrin receptor 1 (TfR1) in adipocytes (72)
Such a nutrient addiction can be targeted for therapy because many cancer cells have limited energy and nutrient flexibility [25,26,38]
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities
Relapse is driven by Tumor Initiating Cells (TICs), a subset of tumor cells capable of regrowing the tumor and highly resistant to therapy
