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[DOI] [PubMed] [Google Scholar] 89.Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M

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This NAD+ elevation activates sirtuins (particularly SIRT1), enhances mitochondrial function, and preserves methylation capacity by reducing S-adenosylmethionine (SAM) consumption

This review will focus on the roles of NNMT in obesity and T2D, as it has been found that the expression of this methyltransferase is elevated in the white adipose tissue and liver of obese people and diabetic mice and that NNMT knockdown protects against diet-induced obesity and insulin resistance [11]