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Researcher Loren Pickart, PhD, who first isolated GHK from human plasma, described it as having a "profound effect on the reset of human genes toward a more youthful state." More recent genomic analyses confirm that GHK-Cu shifts gene expression patterns in aging tissue toward patterns characteristic of much younger tissue effectively acting as a biological reset at the cellular level

Together, these in vitro results suggest that lipid peroxidation, a surrogate of oxidative stress, can further exacerbate NLRP3-inflammasome activation by amplifying the induction of pro-IL-1 in response to SARS-CoV-2

Given the exhaustion of GSH is a pivotal mechanism in ferroptosis, these findings support the notion that ferroptosis may be a key pathological process in intrinsic DILI