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Metabolic Inflexibility Metabolic flexibility is the capacity of the body to use different energy sources depending on the circumstances and availability of oxygen, substrates, and nutrient cofactors

Pharmacological effects and clinical applications of propionyl-L-carnitine

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Farrell M.R., Ziegelmann M.J., Levine L.A

When oxidative stress causes excessive generation of oxygen free radicals, keap1 protein releases Nrf2 through the release of zinc ions, followed by the entrance of Nrf2 into the nucleus to bind to the ARE anti-oxidative stress element sequence, and activates gene transcription downstream of the ARE region, which then initiates the oxidative stress response and reduces the oxidative stress