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PLoS One 5:e9979
Thirdly, methylation occurs by catechol-O-methyltransferases (COMT), which produces metabolites such as homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC)

A positive effect of antioxidant treatments in protection of mice from the development of cerebral malaria and cognitive impairments indicates a role for oxidative stress in the pathogenesis of this complication (Thumwood et al., 1989
