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interaction of chloroacetamide electrophiles with cellular glutathion Targeting a Therapy-Resistant Cancer Cell State Using Masked as GPX4 Inhibitors Direct Interaction between N-Acetylcysteine and
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ROS production Intracellular ROS can be produced by various systems, including mitochondrial electron transport chain (ETC), NADPH oxidase (NOX), cytochrome P450, lipoxygenase, xanthine oxidase, nitric oxide synthase, and cyclooxygenase [9]

In particular, inhibition of IL-1 by canakinumab, the monoclonal antibody (Mab), had a positive therapeutic effect

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Acta Pharmacol Sin 2006;27:146773
