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(2) AHK-Cu (Copper Tripeptide-3) Full name: Alanyl-Histidyl-Lysine Copper Complex Chemical formula: CHCuNO Structural characteristics: Alanine (Ala) replaces glycine to form Ala-His-Lys-Cu complex

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Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

In this study, the high molecular weight HA used in combination with AOD9604 may have further supported chondrocyte survival and matrix synthesis, contributing to the observed improvements in cartilage morphology and function