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Thus, combination of dual PPAR/ agonists and activation of the SIRT1-PGC1 axis holds promise for future therapeutic applications in type 2 diabetes if the same observations are reproduced with other dual PPAR/ dual agonists

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By understanding the causes and mechanisms of leaky gut, as well as implementing appropriate dietary and lifestyle changes, individuals can take steps towards promoting gut health and potentially mitigating the risk or managing autoimmune conditions
