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Although they are promising anti-cataract drugs, these drugs have little effect on nuclear cataracts, suggesting multiple variables restrict their therapeutic effect (150,161), such as the lens nuclear barrier (150)

The inflammasome pathway also links ferroptosis to inflammation

GST polymorphisms, especially the genetic variants of GSTM1 and GSTT1 , have been extensively studied and are reported to associate with INH hepatotoxicity in clinic123, 124

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