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CBS mice rarely live past two weeks and exhibit a variety of abnormalities, which include growth retardation, severe hepatopathy, vascular abnormalities, dislocation of the eyelens and skeletal deformities (Watanabe et al ., 1995

Whereas the sugar thiolate groups were substituted by the histone ligand through the histidine delta nitrogen side chains, the triethyl phosphine groups make hydrophobic interactions with surrounding H3 residues

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