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CBS mice rarely live past two weeks and exhibit a variety of abnormalities, which include growth retardation, severe hepatopathy, vascular abnormalities, dislocation of the eyelens and skeletal deformities (Watanabe et al ., 1995

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Whereas the sugar thiolate groups were substituted by the histone ligand through the histidine delta nitrogen side chains, the triethyl phosphine groups make hydrophobic interactions with surrounding H3 residues

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