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Reducing Inflammation: Inflammation is a normal part of the healing process, but excessive inflammation can hinder recovery and contribute to chronic conditions

Taking certain medications regularly can also cause this

Patients should seek medical evaluation for severe pain after injury, inability to bear weight, major swelling, deformity, numbness, weakness, fever, signs of infection, worsening abdominal pain, blood in stool, persistent vomiting, chest pain, shortness of breath, or neurological symptoms

GDF11 and GDF8 are members of the Activin subclass which signals through ALK4, ALK5, and ALK7 members of the Type I receptors