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The liver and kidneys are two of the main detoxification organs in the body

Energy expenditure : Retatrutide's glucagon component directly increases energy expenditure

It is also possible that generation of nicotinamide by CD38 may regulate SIRTUINs activity, since nicotinamide is an endogenous inhibitor of the SIRTUINs [62-63]

The cytoprotection concept holds innate cell (epithelial (Robert) [41,42,43], endothelial (Szabo) [44,45,46,47]) integrity, even against opposite damaging necrotizing agents (i.e., strong alcohol, boiling water, strong acid, strong base [41]) and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection organoprotection) [48,49] via the cytoprotection agents effect