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Int J Infect Dis (2022) 124:110
doi: 10.1007/s40263-013-0130-6
Elevated homocysteine and aberrant FOCM have also been reported in Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Huntingtons disease and are associated with neuroinflammation, demyelination, neuronal loss, and severe disease phenotypes in these conditions
Surprisingly, EZH2 depletion in KRAS G12D-driven PDAC resultes in a significant reduction of NFATC1 expression, suggesting KRAS serves as a regulatory switch modifying EZH2 responsive function on NFATC1 expression [149]
