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Conformational changes of these conserved residues especially the transmission switch residues F272 6.44 and W276 6.48 have been suggested to link the extracellular agonist-binding to the cytoplasmic receptor activation and G protein-coupling for class A GPCRs (Supplementary Fig

doi: 10.1089/ars.2011.4391
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10.2174/1874609811205030012 181 VaisermanA.KoliadaA.LushchakO.CastilloM
44, Nov
