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Among the seven conserved functional areas referred to as the Nrf2-ECH homology (Neh) domains of Nrf2, Neh1 primarily dimerises and attaches to small Maf (sMAF) proteins before going on to bind to DNA [13, 14]
The most noticeable effect observed after chronic THC exposure is the significant but reversible reduction in CB 1 Rs, with cortical regions showing more extensive decreases in expression (Hirvonen et al., 2012
