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The Bile salt export pump (BSEP) and small heterodimer protein (SHP) are known targets of the FXR signaling pathway, and their transcriptional induction expression is regulated when the FXR signaling pathway is activated [284]
H.RenB.et al (2021)
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In the pathology of OA, cellular iron overload can increase localized inflammatory mediators, contributing to OA development ( 2.2 Lipid peroxidation A disruption of cell membrane integrity, which can lead to cell death, represents one potential mechanism through which ferroptosis occurs
