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Ma S-J, Li C, Yan C, Liu N, Jiang G-Y, Yang H-R, et al

Ferroptosis is characterized by the depletion of intracellular GSH and decreased activity of GPx4, which in turn results in the accumulation of lipid peroxides and Fe(II)-catalyzed oxidation of lipids by the Fenton reaction and increased ROS formation

Astaxanthin also confers protective effects against neurotoxicity at 60 mg/kg dose

They were speculated to be minor positional isomers resulting from addition of CN to different positions on the piperazine ring, or potentially from monohydroxylation on positions on the phenoxyethyl-5-ethyltriazolone propyl motif rather than the 5-ethyl side chain (Scheme 1)